Trans-Resveratrol is the biologically active isomer of resveratrol, a stilbene found in grapes and other plants. It is known to activate sirtuin proteins (particularly SIRT1), which are involved in cellular stress responses, mitochondrial function, and metabolic regulation.
Fisetin is a flavonoid present in fruits and vegetables such as strawberries and apples. It has attracted scientific interest for its antioxidant properties and its classification as a senolytic compound in preclinical models—meaning it may help modulate the accumulation of senescent (aging) cells.
Together, trans-resveratrol and fisetin are often explored for their potential to support cellular homeostasis, oxidative stress resistance, and pathways associated with healthy aging, though human clinical evidence is still evolving.